Isofol Medical

Isofol is a clinical stage pharmaceutical company developing novel products for unmet needs within oncology. Isofol’s lead clinical candidate, Modufolin®, is predicted to improve the outlook for cancer patients undergoing chemotherapy treatment with a range of antimetabolites. Isofol’s ongoing clinical trials are focusing on colorectal cancer and osteosarcoma. Isofol collaborates closely with its strategic R&D partner Merck Millipore, the world’s leading manufacturer of reduced folates.

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Modufolin® development

Modufolin® is a folate-based bio-modulator designed to replace leucovorin/levoleucovorin as the preferred treatment to enhance the activity and reduce associated toxicity of the widely used cancer chemotherapeutic agent 5-FU (5-flluorouracil). It is currently being evaluated in three Phase I/II studies, two in colorectal cancer and one in osteosarcoma.
 
Although several modern chemo drugs have been introduced that dramatically improve the treatment of many cancer diseases, they show limited effect in treating solid tumors. 5-FU and leucovorin/levoleucovorin is still the core treatment used today for colorectal cancer and Modufolin® has the potential to enable 5-FU to work more effectively.

Read more about Modufolin

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News & Press information

Recipharm forms new collaboration with Isofol Medical to exclusively manufacture Modufolin® and invests SEK 8 million in the company
8/26/2014: Recipharm and Isofol Medical AB, a Gothenburg-based pharmaceutical company developing novel products for unmet needs within oncology, are pleased to announce the formation of a collaboration to strengthen the development program of Isofol’s lead drug candidate Modufolin®.
Merck and Isofol enter into an exclusive supply & license agreement
6/4/2013: Isofol Medical AB announced today that they have expanded the existing agreement and entered into a worldwide exclusive supply & license agreement with Merck KGaA and Merck & Cie (Merck) for the use of [6R]-5,10-methylenetetrahydrofolate (also known as Modufolin®) in cancer treatment.
Isofol Medical AB, Biotech Center, Arvid Wallgrens Backe 20, SE-413 46 Gothenburg, Sweden
Phone: +46 (0) 707 64 65 00 / +46 (0) 739 89 55 28 E-mail: info@isofolmedical.com