Isofol Medical's lead clinical candidate Modufolin® ([6R] 5,10-methylene tetrahydrofolate) is currently being evaluated for the treatment of rectal cancer in the clinical phase I/II study ISO-MC-091 (NCT01397305). The study evaluates the feasibilty of neoadjvant treatment with Modufolin® in combination with pemetrexed. A second clinical trial on Modufolin®, evaluating pharmacokinetic characteristics, will be launched during Q2 2012. An extensive pre-clinical safety program is ongoing and will be completed during 2012. Read more about the development pipeline
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News & Press information
Merck and Isofol enter into an exclusive supply & license agreement
Isofol Medical AB announced today that they have expanded the existing agreement and entered into a worldwide exclusive supply & license agreement with Merck KGaA and Merck & Cie (Merck) for the use of [6R]-5,10-methylenetetrahydrofolate (also known as Modufolin®) in cancer treatment.
Modufolin® shows positive pre-clinical and clinical results
Isofol Medical AB today announced that it successfully has completed the first part of its preclinical
safety program on Modufolin®. The GLP program performed shows no Modufolin®-
related toxicity in animals. Preliminary data from two separate clinical trials also show that
Modufolin® is safe when administered to patients in the dose range evaluated.
The company has also recently received preliminary data which indicates that Modufolin®
enables substantially greater exposure to and peak concentrations of MTHF than those
obtained after administration of Levoleucovorin (L-LV).